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II Einige Studien zu Vitamin B12 und Folsäure bei der Behandlung der Vitiligo (1 bis 5):

(In der Reihenfolge der Veröffentlichung)

 
1. [Vitamin B 12 deficiency and vitiligo]
[Vitamin-B12-Mangel und Vitiligo.]
Blut 1969 Jul;19(4):223-5    (ISSN: 0006-5242)
Bleifeld W; Gehrmann G

 
2. [Vitamin B 12 resorption studies in vitiligo]
[Vitamin-B12-Resorptionsstudien bei Vitiligo.]
Dtsch Med Wochenschr 1967 Jun 9;92(23):1072-4    (ISSN: 0012-0472)
Bleifeld W; Gehrmann G

 
3. Pernicious anemia, vitiligo, and infertility.
J Am Board Fam Pract 1990 Jul-Sep;3(3):217-20    (ISSN: 0893-8652)
Gulden KD
Wilkes Family Health Center, North Wilkesboro, NC.
Though rarely encountered in women of childbearing age, untreated pernicious anemia has been found to be a cause of infertility. Once treated, conception often occurs within months. The case presented here is a woman who had a restoration of fertility after initiation of vitamin B12 treatment for vitiligo-associated pernicious anemia. Previous reports have shown the occurrence of pregnancy in treated pernicious anemia, but none has indicated the presence of vitiligo in the same patient. Pernicious anemia is a rare but treatable cause of infertility in women.

 
4. Folic acid and vitamin B12 in vitiligo: a nutritional approach.
Cutis 1992 Jul;50(1):39-42    (ISSN: 0011-4162)
Montes LF; Diaz ML; Lajous J; Garcia NJ
Department of Dermatology, University of Alabama, Birmingham Medical Center.
When compared with the normal population, patients with vitiligo often showed diminished blood levels of folic acid. In a group of fifteen patients with vitiligo, folic acid levels were below normal in the serum of eleven patients, in the whole blood of five patients, and in the erythrocytes of six patients. Vitamin B12 serum levels were below normal in five of the fifteen patients. Ascorbic acid plasma levels were also lowered in four of the patients. In eight patients prolonged oral administration of folic acid with simultaneous parenteral treatment with vitamin B12 and oral ascorbic acid was followed by definite repigmentation without side effects.

 
5. Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the importance of sun exposure.
Acta Derm Venereol 1997 Nov;77(6):460-2    (ISSN: 0001-5555)
Juhlin L; Olsson MJ
Department of Dermatology, University Hospital, Uppsala, Sweden.
The aim of this 2-year study was to test the hypothesis that folic acid, vitamin B12 and sun exposure could be helpful in treating vitiligo. One hundred patients with vitiligo were treated with oral folic acid and vitamin B12 after being informed that sun exposure might enhance repigmentation. They were requested to keep a record of sun exposure in summer and UVB irradiation in winter. The minimal treatment time suggested was 3-6 months but should be longer if improvement was achieved. Clear repigmentation occurred in 52 patients, including 37 who exposed their skin to summer sun and 6 who used UVB lamps in winter. Repigmentation was most evident on sun-exposed areas, where 38% of the patients had previously noted repigmentation during summer months. Total repigmentation was seen in 6 patients. The spread of vitiligo stopped in 64% of the patients after treatment. Folic acid and vitamin B12 supplementation combined with sun exposure can induce repigmentation better than either the vitamins or sun exposure alone. Treatment should continue as long as the white areas continue to repigment. Further studies are needed to determine ideal minimal dosages of vitamins and UV exposure, as well as treatment time.